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KMID : 1234920160160010027
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Journal of Korean Oriental Association for Study of Obesity
2016 Volume.16 No. 1 p.27 ~ p.35
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Antiobesity Effect of Water Extract of Coix lacrymajobi var. mayuen in High Fat Fed C5BL/6 Mice
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Song Mi-Young
Jung Hyo-Won
Park Yong-Kee
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Abstract
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Objectives: This study investigated the effects of water extract of Coix lacrymajobi var. mayuen on obesity and its associated factors in high fat diet (HFD) induced obese mice.
Methods: Male C5BL/6 mice were randomly assigned to 4 groups, normal group (chow diet), a HFD, HFD with water extract of Coix lacrymajobi var. mayuen 100 mg/kg (W-Coix), and HFD with phentermine 5 mg/kg (Phen) as positive control. Body weight, food intake, fasting blood glucose were checked every week and then organs, blood serums were collected after 16 weeks of treatment.
Results: Body weight and adipocyte size were significantly lesser in W-Coix than in HFD group; however energy efficiency in W-Coix were not different with HFD. The oral glucose tolerance test, serum glucose and insulin were significantly decreased in W-Coix, also lipid accumulations in liver tissue and lipid levels (total cholesterol, high density lipoprotein-cholesterol) were improved with W-Coix treatment. However skeletal muscle loss with HFD was not changed in W-Coix compared with HFD group.
Conclusions: The W-Coix treatment decreased body weight, adipocyte size and it is associated with improved glucose and lipid metabolism. Further studies are needed to know the mechanism of antiobesity in W-Coix.
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KEYWORD
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Coix lacrymajobi var. mayuen, C5BL/6 mouse, Obesity, Glucose, Lipid, Liver
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